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ribociclib will boost the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.etravirine will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of fentanyl with CYP3A4 inducers may lead to some lower in fentanyl plasma con